Combinatorial Synthesis of Peptidomimetics Using Digital Microfluidics
نویسندگان
چکیده
A microfluidic technique for combinatorial chemical synthesis of peptidomimetics has been developed. The new 32step method is fast, automated and includes an integrated magnetic separation of inorganic catalysts from reaction products. This proof-of-concept study should lead to methods for generating libraries of compounds suitable for screening for bioactivity.
منابع مشابه
High throughput synthesis of peptides and peptidomimetics.
Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a number of ingenious strategies. Optimization, in particular, has been achieved in stepwise solid phase synthesis. This in turn made possible the development of ...
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